Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated …

SE Smith-Jeffcoat, JE Biddle, HK Talbot… - Clinical Infectious …, 2024 - academic.oup.com
Abstract Background Nirmatrelvir/ritonavir (N/R) reduces severe outcomes from coronavirus
disease 2019 (COVID-19); however, rebound after treatment has been reported. We …

[PDF][PDF] 930. COVID-19 symptom and viral load rebound among individuals reporting nirmatrelvir/ritonavir use compared to propensity score matched individuals not …

SE Smith-Jeffcoat, JE Biddle, HK Talbot… - Open Forum …, 2023 - academic.oup.com
Abstract Background Nirmatrelvir/ritonavir (N/R) protects against severe outcomes after
SARS-CoV-2 (SCV2) infection, but patients and studies have described symptom and viral …

Predictors of nirmatrelvir–ritonavir receipt among COVID-19 patients in a large US health system

DE Malden, JM McLaughlin, V Hong, J Lewnard… - Scientific Reports, 2024 - nature.com
A clear understanding of real-world uptake of nirmatrelvir–ritonavir for treatment of SARS-
CoV-2 can inform treatment allocation strategies and improve interpretation of effectiveness …

Nirmatrelvir/ritonavir utilization for the treatment of non-hospitalized adults with COVID-19 in the National Veterans Affairs (VA) Healthcare System

HJ Appaneal, KL LaPlante, VV Lopes, C Martin… - Infectious Diseases and …, 2024 - Springer
Introduction Limited data exist regarding real-world utilization of nirmatrelvir/ritonavir. We
identified predictors of nirmatrelvir/ritonavir use among Veterans Affairs (VA) outpatients …

Association of nirmatrelvir for acute SARS‐CoV‐2 infection with subsequent Long COVID symptoms in an observational cohort study

MS Durstenfeld, MJ Peluso, F Lin… - Journal of Medical …, 2024 - Wiley Online Library
Oral nirmatrelvir/ritonavir is approved as treatment for acute COVID‐19, but the effect of
treatment during acute infection on risk of Long COVID is unknown. We hypothesized that …

The coronavirus disease 2019 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with nirmatrelvir …

JA Pandit, JM Radin, DC Chiang… - Clinical Infectious …, 2023 - academic.oup.com
Background The uptake of nirmatrelvir plus ritonavir (NPR) in patients with coronavirus
disease 2019 (COVID-19) has been limited by concerns around the rebound phenomenon …

Association of Nirmatrelvir/Ritonavir Treatment with Long COVID Symptoms in an Online Cohort of Non-Hospitalized Individuals Experiencing Breakthrough SARS …

MS Durstenfeld, MJ Peluso, F Lin, ND Peyser, C Isasi… - medRxiv, 2023 - medrxiv.org
Background Oral nirmatrelvir/ritonavir is a treatment for COVID-19, but whether treatment
during the acute phase reduces the risk of developing Long COVID is unknown. Methods …

1156. Sustained alleviation and resolution of targeted COVID-19 symptoms with nirmatrelvir/ritonavir versus placebo

J Hammond, H Leister-Tebbe, A Gardner… - Open Forum …, 2022 - academic.oup.com
Background Nirmatrelvir with ritonavir (nirmatrelvir/r) is an oral antiviral COVID-19 treatment.
We report its efficacy to shorten time to sustained alleviation and resolution of COVID-19 …

[HTML][HTML] Viral load rebound in placebo and nirmatrelvir-ritonavir treated COVID-19 patients is not associated with recurrence of severe disease or mutations

H Soares, ML Baniecki, R Cardin, H Leister-Tebbe… - 2022 - europepmc.org
Nirmatrelvir-ritonavir was developed for the treatment of COVID-19 and has shown efficacy
in a Phase 2/3 study of high risk patients (EPIC-HR1). Monitoring for the emergence of viral …

Clinical, virologic, and immunologic evaluation of symptomatic coronavirus disease 2019 rebound following nirmatrelvir/ritonavir treatment

BP Epling, JM Rocco, KL Boswell… - Clinical Infectious …, 2023 - academic.oup.com
Background Nirmatrelvir/ritonavir, the first severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) protease inhibitor, reduces the risk of hospitalization and death by …