Medicine and dentistry interface at many levels. For example, the focal infection theory,
popular at the outset of the 1900s, suggested that systemic ailments could be traced to …

Rheumatoid arthritis (RA), an autoimmune disease that affects∼ 1% of the human
population, is driven by autoantibodies that target modified self-epitopes, whereas∼ 11% of …

Studies of clinical oral health parameters, the gingival microenvironment, autoantibodies
and biomarkers, and rheumatoid arthritis disease activity measures are providing a better …

Our understanding of the pathogenesis in human periodontal diseases is limited by the lack
of specific and sensitive tools or models to study the complex microbial challenges and their …

Periodontitis and rheumatoid arthritis (RA) appear to share many pathologic features. In this
review, the common pathologic mechanisms of these two common chronic conditions are …

The elderly exhibit increased susceptibility to a number of inflammatory or degenerative
pathologies. Aging is similarly thought to be associated with increased prevalence and …

In periodontitis, dysbiotic microbial communities exhibit synergistic interactions for enhanced
protection from host defenses, nutrient acquisition, and persistence in an inflammatory …

The last decade has witnessed unparalleled advances in our understanding of the
complexity of the oral microbiome and the compositional changes that occur in subgingival …

The concept of inflammation has a long history. Although an inflammatory response to injury
or another trigger is necessary, chronic diseases, such as coronary heart disease and …

Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …