Single-cell RNA sequencing reveals key molecular drivers and immune landscape in uveal melanoma: implications for targeted therapy and prognostic modeling
Z Song, W Shao, Z Xiahou, Y Xu, X Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Background Uveal melanoma (UM), arising from melanocytes in the choroid, accounts for
3% to 5% of all melanocytic tumors and over 70% of intraocular malignancies. Despite …
3% to 5% of all melanocytic tumors and over 70% of intraocular malignancies. Despite …
Single-cell and bulk transcriptome analysis reveals tumor cell heterogeneity and underlying molecular program in uveal melanoma
K Li, J Huang, Y Tan, J Sun, M Zhou - Journal of Translational Medicine, 2024 - Springer
Background Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic
potential. Despite the predominance of malignant cells within the tumor microenvironment …
potential. Despite the predominance of malignant cells within the tumor microenvironment …
Single-Cell RNA Sequencing and AlphaFold 3 Insights into Cytokine Signaling and Its Role in Uveal melanoma
HY Sun, C Li, Z Pu, Y Lu, Z Wu, L Zhou, H Lin… - Frontiers in …, 2025 - frontiersin.org
Background: Uveal melanoma (UVM) is a form of eye cancer with a poor prognosis,
particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity …
particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity …
Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma
S Sun, B Guo, L Xu, R Shi - BMC cancer, 2022 - Springer
Background Uveal melanoma (UM) is the most common primary intraocular malignancy with
a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The …
a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The …
Uveal melanoma: from lab bench to clinic–new therapeutic advances
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a
high propensity for metastasis and, historically, a lack of effective treatment options for late …
high propensity for metastasis and, historically, a lack of effective treatment options for late …
[HTML][HTML] 1498 Deploying spatial transcriptomics to inform on intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and …
S Srinivasan, J Rose, JR Daniele, M Peoples, M He… - 2023 - jitc.bmj.com
Background Uveal melanoma (UM) is a rare tumor characterized by mutually exclusive
activating mutations in GNAQ in GNA11, followed by secondary events in BAP1, SF3B1 and …
activating mutations in GNAQ in GNA11, followed by secondary events in BAP1, SF3B1 and …
Identification of heterogeneity and prognostic key genes associated with uveal melanoma using single-cell RNA-sequencing technology
S Sun, R Shi, L Xu, F Sun - Melanoma Research, 2022 - journals.lww.com
Uveal melanoma (UM) is the most common intraocular malignancy in adults. The prognosis
is poor once metastasis has developed. The treatment of metastatic UM remains challenging …
is poor once metastasis has developed. The treatment of metastatic UM remains challenging …
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma
H Shi, H Tian, T Zhu, Q Liao, C Liu, P Yuan, Y Li… - Cell Discovery, 2024 - nature.com
Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant
metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical …
metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical …
Integrating Single-cell and Bulk RNA-seq to Construct a Metastasis-related Model for Evaluating Immunotherapy and Chemotherapy in Uveal Melanoma
Y Du, X Jiang, Y Zhang, J Ying… - Current Medicinal …, 2024 - ingentaconnect.com
Background: Metastasis is a major cause of death in UM, highlighting the need to use highly
specific and sensitive prognostic markers to identify patients with a risk of developing …
specific and sensitive prognostic markers to identify patients with a risk of developing …
Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior
K Li, L Sun, Y Wang, Y Cen, J Zhao, Q Liao… - … & Molecular Medicine, 2023 - nature.com
Uveal melanoma (UM) is the most frequent primary intraocular malignancy with high
metastatic potential and poor prognosis. Macrophages represent one of the most abundant …
metastatic potential and poor prognosis. Macrophages represent one of the most abundant …