Ischemic retinopathies, such as diabetic retinopathy (DR), retinopathy of prematurity and
retinal vein occlusion are a major cause of blindness in developed nations worldwide. Each …

Retinal neovascularization is a leading cause of visual disability. Retinal diseases involving
neovascularization all follow the same progression, beginning with vascular inflammatory …

We have shown previously that diabetes causes increases in retinal arginase activity that
are associated with impairment of endothelial cell (EC)-dependent vasodilation and …

Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans.
Clinicians diagnose DR based on its characteristic vascular pathology, which is evident …

Arginase has been reported to reduce nitric oxide bioavailability in cardiovascular disease.
However, its specific role in retinopathy has not been studied. In this study, we assessed the …

Hyperoxia treatment has been known to induce neuronal and glial death in the developing
central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in …

Ischemic retinopathies represent a major cause of visual impairment and blindness. They
include diabetic retinopathy (DR), acute glaucoma, retinopathy of prematurity (ROP), and …

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major
clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 …

Objective Retinal ischemic disease is a major cause of vision loss. Current treatment options
are limited to late-stage diseases, and the molecular mechanisms of the initial insult are not …

Background Hyperoxia exposure of premature infants causes obliteration of the immature
retinal microvessels, leading to a condition of proliferative vitreoretinal neovascularization …