Multivalent nanoparticle binding to cells can be of picomolar avidity making such
interactions almost as intense as those seen with antibodies. However, reducing …

The conjugation of receptor ligands to shielded nanoparticles is a widely used strategy to
precisely control nanoparticle–cell interactions. However, it is often overlooked that a …

Nanotechnology is finding ever increasing application in the life science arena where
nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the …

Although there are a large number of studies available for the evaluation of the therapeutic
efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that …

With the rapid development of biotechnology and nanomedicine, extensive research has
focused on the investigations of delivering large-cargo molecules using nanoparticles …

Nanoparticles (NPs) can be taken up by cells; however, the effects of the structural
characteristics of NPs on their cellular internalization have not been well explored. In this …

Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …

Most nanoparticles' parameters affect their interactions with cells. To date, all the parameters
studied are basically static (eg, size, shape, ligands, and charge). This is unfortunate …

Dual ligand targeting to different types of over-expressed receptors on cell surfaces is a
promising strategy in nanomedicine. Here, by using dissipative particle dynamics …

Nanoparticles and their interaction with human cells have been a focus of many groups
during the past decade. We discuss and review here the progress in the field of …