Deep learning prediction of adverse drug reactions in drug discovery using open TG–GATEs and FAERS databases

A Mohsen, LP Tripathi, K Mizuguchi - Frontiers in Drug Discovery, 2021 - frontiersin.org
Machine learning techniques are being increasingly used in the analysis of clinical and
omics data. This increase is primarily due to the advancements in Artificial intelligence (AI) …

Prediction of drug adverse events using deep learning in pharmaceutical discovery

CY Lee, YPP Chen - Briefings in Bioinformatics, 2021 - academic.oup.com
Traditional machine learning methods used to detect the side effects of drugs pose
significant challenges as feature engineering processes are labor-intensive, expert …

ADENet: a novel network-based inference method for prediction of drug adverse events

Z Yu, Z Wu, W Li, G Liu, Y Tang - Briefings in Bioinformatics, 2022 - academic.oup.com
Identification of adverse drug events (ADEs) is crucial to reduce human health risks and
improve drug safety assessment. With an increasing number of biological and medical data …

Predicting drug-drug interactions using deep neural network

X Hou, J You, P Hu - Proceedings of the 2019 11th International …, 2019 - dl.acm.org
Drug-drug interactions (DDIs) can trigger unexpected pharmacological effects, including
adverse drug events (ADEs), with causal mechanisms often unknown. Recently, deep …

[HTML][HTML] Application of artificial intelligence and machine learning in early detection of adverse drug reactions (ADRs) and drug-induced toxicity

S Yang, S Kar - Artificial Intelligence Chemistry, 2023 - Elsevier
Adverse drug reactions (ADRs) and drug-induced toxicity are major challenges in drug
discovery, threatening patient safety and dramatically increasing healthcare expenditures …

Rapid assessment of adverse drug reactions by statistical solution of gene association network

YP Xiang, K Liu, XY Cheng, C Cheng… - … ACM transactions on …, 2014 - ieeexplore.ieee.org
Adverse drug reaction (ADR) is a common clinical problem, sometimes accompanying with
high risk of mortality and morbidity. It is also one of the major factors that lead to failure in …

Machine-learning-based adverse drug event prediction from observational health data: A review

J Denck, E Ozkirimli, K Wang - Drug Discovery Today, 2023 - Elsevier
Adverse drug events (ADEs) are responsible for a significant number of hospital admissions
and fatalities. Machine learning models have been developed to assess individual patient …

Prediction of adverse drug reaction linked to protein targets using network-based information and machine learning

C Galletti, J Aguirre-Plans, B Oliva… - Frontiers in …, 2022 - frontiersin.org
Drug discovery attrition rates, particularly at advanced clinical trial stages, are high because
of unexpected adverse drug reactions (ADR) elicited by novel drug candidates. Predicting …

DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions

Z Liang, JX Huang, X Zeng, G Zhang - BMC medical genomics, 2016 - Springer
Background Genomic variations are associated with the metabolism and the occurrence of
adverse reactions of many therapeutic agents. The polymorphisms on over 2000 locations of …

Machine learning workflow to enhance predictions of Adverse Drug Reactions (ADRs) through drug-gene interactions: application to drugs for cutaneous diseases

K Raja, M Patrick, JT Elder, LC Tsoi - Scientific reports, 2017 - nature.com
Adverse drug reactions (ADRs) pose critical public health issues, affecting over 6% of
hospitalized patients. While knowledge of potential drug-drug interactions (DDI) is …