Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging

BC Dickerson, RA Sperling - Behavioural neurology, 2009 - content.iospress.com
Functional MRI (fMRI) studies of mild cognitive impairment (MCI) and Alzheimer's disease
(AD) have begun to reveal abnormalities in large-scale memory and cognitive brain …

Functional connectivity in neurodegenerative disorders: Alzheimer's disease and frontotemporal dementia

R Jalilianhasanpour, E Beheshtian… - Topics in Magnetic …, 2019 - journals.lww.com
Neurodegenerative disorders are a growing cause of morbidity and mortality worldwide.
Onset is typically insidious and clinical symptoms of behavioral change, memory loss, or …

Resting functional connectivity reveals residual functional activity in Alzheimer's disease

G Zamboni, GK Wilcock, G Douaud, E Drazich… - Biological …, 2013 - Elsevier
Background Functional magnetic resonance imaging (fMRI) has great potential for
measuring mechanisms of functional changes in Alzheimer's disease (AD) and mild …

Increased functional connectivity within medial temporal lobe in mild cognitive impairment

SR Das, J Pluta, L Mancuso, D Kliot, S Orozco… - …, 2013 - Wiley Online Library
Pathology at preclinical and prodromal stages of Alzheimer's disease (AD) may manifest
itself as measurable functional change in neuronal networks earlier than detectable …

Resting state functional connectivity in preclinical Alzheimer's disease

YI Sheline, ME Raichle - Biological psychiatry, 2013 - Elsevier
There has been a dramatic increase in the number of studies using resting state functional
magnetic resonance imaging (rs-fMRI), a recent addition to imaging analysis techniques …

Functional MRI of mnemonic networks across the spectrum of normal aging, mild cognitive impairment, and Alzheimer's disease

JP Chhatwal, RA Sperling - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Functional magnetic resonance imaging (fMRI) is a non-invasive technique that has come
into common use to examine neural network function in normal and impaired cognitive …

Functional MRI assessment of task‐induced deactivation of the default mode network in Alzheimer's disease and at‐risk older individuals

M Pihlajamäki, RA Sperling - Behavioural neurology, 2009 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia in old age, and is
characterized by prominent impairment of episodic memory. Recent functional imaging …

Functional alterations in memory networks in early Alzheimer's disease

RA Sperling, BC Dickerson, M Pihlajamaki… - Neuromolecular …, 2010 - Springer
The hallmark clinical symptom of early Alzheimer's disease (AD) is episodic memory
impairment. Recent functional imaging studies suggest that memory function is subserved …

Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies

BC Dickerson, RA Sperling - Neuropsychologia, 2008 - Elsevier
Functional MRI (fMRI) studies of mild cognitive impairment (MCI) and Alzheimer's disease
(AD) have begun to reveal abnormalities in memory circuit function in humans suffering from …

Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease

HY Zhang, SJ Wang, J Xing, B Liu, ZL Ma… - Behavioural brain …, 2009 - Elsevier
Resting-state networks dissociate in the early stage of Alzheimer's disease (AD). The
posterior cingulate cortex (PCC) in AD brain is vulnerable to isolation from the rest of brain …