Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Since their recent development, organoids that emulate human brain tissue have allowed in
vitro neural development studies to go beyond the limits of monolayer culture systems, such …

Cerebral organoids, or brain organoids, can be generated from a wide array of emerging
technologies for modeling brain development and disease. The fact that they are cultured in …

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development,
thus offering an innovative tool by which to model human neurodevelopmental disease. We …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

Scientists have been fascinated by the human brain for centuries, yet knowledge of the
cellular and molecular events that build the human brain during embryogenesis and of how …

Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …

Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …

Brain organoids are an exciting new technology with the potential to significantly change our
understanding of the development and disorders of the human brain. With step-by-step …

Brain organoids are 3D self-assembled structures composed of hundreds of thousands to
millions of cells that resemble the cellular organization and transcriptional and epigenetic …