Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Mechanism of action of small-molecule agents in ongoing clinical trials for SARS-CoV-2: a review

L Zhao, S Li, W Zhong - Frontiers in Pharmacology, 2022 - frontiersin.org
Since the first reports from December 2019, COVID-19 caused an overwhelming global
pandemic that has affected 223 countries, seriously endangering public health and creating …

COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?

WS Ho, R Zhang, YL Tan, CLL Chai - Pharmacological Research, 2022 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic had grounded the world to a
standstill. As the disease continues to rage two years on, it is apparent that effective …

The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2

I Ahmad - European journal of medicinal chemistry, 2021 - Elsevier
The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in …

Chinese therapeutic strategy for fighting COVID-19 and potential small-molecule inhibitors against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

N Choudhry, X Zhao, D Xu, M Zanin… - Journal of medicinal …, 2020 - ACS Publications
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has led to more than 20 million people infected worldwide with …

A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19)

F Huang, Y Li, ELH Leung, X Liu, K Liu, Q Wang… - Pharmacological …, 2020 - Elsevier
The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2)
infection has been listed as a public health emergency of international concern by the World …

After the hurricane: Anti-COVID-19 drugs development, molecular mechanisms of action and future perspectives

HO Khalifa, YM Al Ramahi - International Journal of Molecular Sciences, 2024 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …

[HTML][HTML] Recent advances in developing small-molecule inhibitors against SARS-CoV-2

R Xiang, Z Yu, Y Wang, L Wang, S Huo, Y Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across
the entire world. Even though several COVID-19 vaccines are currently in distribution …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19

AK Ghosh, JL Mishevich, A Mesecar… - ChemMedChem, 2022 - Wiley Online Library
Abstract COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public
health crisis around the globe. Development of vaccines and the first cluster of antiviral …