The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

AT Virtue, SJ McCright, JM Wright… - Science translational …, 2019 - science.org
The gut microbiota is a key environmental determinant of mammalian metabolism.
Regulation of white adipose tissue (WAT) by the gut microbiota is a process critical to …

A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut

SP Mishra, B Wang, S Jain, J Ding, J Rejeski… - Gut, 2023 - gut.bmj.com
Objective Ample evidence exists for the role of abnormal gut microbiota composition and
increased gut permeability ('leaky gut') in chronic inflammation that commonly co-occurs in …

Cross-talk between gut microbiota and adipose tissues in obesity and related metabolic diseases

D Wu, H Wang, L Xie, F Hu - Frontiers in Endocrinology, 2022 - frontiersin.org
The rapid increase of obesity and associated diseases has become a major global health
problem. Adipose tissues are critical for whole-body homeostasis. The gut microbiota has …

Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue

EY Huang, VA Leone, S Devkota… - Journal of Parenteral …, 2013 - Wiley Online Library
Background: Growing evidence shows that dietary factors can dramatically alter the gut
microbiome in ways that contribute to metabolic disturbance and progression of obesity. In …

[HTML][HTML] MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling

YK Cho, Y Son, SN Kim, HD Song, M Kim, JH Park… - Molecular …, 2019 - Elsevier
Objective This study investigated the role of microRNAs generated from adipose tissue
macrophages (ATMs) during adipose tissue remodeling induced by pharmacological and …

Gut microbiota-dependent modulation of energy metabolism

CN Heiss, LE Olofsson - Journal of innate immunity, 2018 - karger.com
The gut microbiota has emerged as an environmental factor that modulates the host's
energy balance. It increases the host's ability to harvest energy from the digested food, and …

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

CL Boulangé, AL Neves, J Chilloux, JK Nicholson… - Genome medicine, 2016 - Springer
The human gut harbors more than 100 trillion microbial cells, which have an essential role in
human metabolic regulation via their symbiotic interactions with the host. Altered gut …

Gut microbiota: an integral moderator in health and disease

Q Feng, WD Chen, YD Wang - Frontiers in microbiology, 2018 - frontiersin.org
The gut microbiota, as the main member in gut microecology, is an essential mediator in
health and disease. The gut microbiota interacts with various organs and systems in the …

Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives

L Sun, L Ma, Y Ma, F Zhang, C Zhao, Y Nie - Protein & cell, 2018 - academic.oup.com
Concern about health risks associated with rising obesity has become nearly universal, with
the mean body mass index (BMI) and the prevalence of obese and overweight individuals …

Microbial modulation of insulin sensitivity

MT Khan, M Nieuwdorp, F Bäckhed - Cell metabolism, 2014 - cell.com
The gut microbiota has emerged as an integral factor that impacts host metabolism and has
been suggested to play a vital role in metabolic diseases such as obesity, insulin resistance …