H3. 3 is a histone variant that marks transcription start sites as well as telomeres and
heterochromatic sites on the genome. The presence of H3. 3 is thought to positively …

Histone H3. 3 is a highly conserved histone H3 replacement variant in metazoans and has
been implicated in many important biological processes, including cell differentiation and …

Canonical histone H3 and histone variant H3. 3 are posttranslationally modified with the
genomic distribution of these marks denoting different features and these modifications may …

H3. 3 is a highly conserved nonreplicative histone variant. H3. 3 is enriched in promoters
and enhancers of active genes, but it is also found within suppressed heterochromatin …

Background The histone variant H3. 3 plays key roles in regulating chromatin states and
transcription. However, the role of endogenous H3. 3 in mammalian cells and during …

Variant histone H3. 3 is incorporated into nucleosomes by a mechanism that does not
require DNA replication and has also been implicated as a potential mediator of epigenetic …

Histone variants can replace canonical histones in the nucleosome and modify chromatin
structure and gene expression. The histone variant H3. 3 preferentially associates with …

Histone variant H3. 3 plays novel roles in development as compared to canonical H3
proteins and is the most commonly mutated histone protein of any kind in human disease …

Histones package DNA and regulate epigenetic states. For the latter, probably the most
important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3. 1 …

Histones are the main protein components of eukaryotic chromatin. Histone variants and
histone modifications modulate chromatin structure, ensuring the precise operation of …