Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns
The SARS-CoV-2 pandemic has highlighted the need for broad-spectrum antiviral drugs to
respond promptly to viral emergence. We conducted a preclinical study of molnupiravir …
respond promptly to viral emergence. We conducted a preclinical study of molnupiravir …
GS-5734: a potentially approved drug by FDA against SARS-Cov-2
Z Wang, L Yang - New Journal of Chemistry, 2020 - pubs.rsc.org
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. COVID-19 is an ongoing global health crisis …
coronavirus 2 (SARS-CoV-2) infection. COVID-19 is an ongoing global health crisis …
A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues
L Min, Q Sun - Signal Transduction and Targeted Therapy, 2022 - nature.com
By February 10, 2022, SARS-CoV-2 has infected more than 400 million people, including
more than 5.79 million deaths. Patients infected with SARS-CoV-2 usually develop mild to …
more than 5.79 million deaths. Patients infected with SARS-CoV-2 usually develop mild to …
Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
L Herrmann, F Hahn, C Wangen… - … A European Journal, 2022 - Wiley Online Library
The presently ongoing pandemic of human SARS‐CoV‐2 infections (COVID‐19) presents
an enormous challenge in surveillance, vaccine and antiviral drug development. Here we …
an enormous challenge in surveillance, vaccine and antiviral drug development. Here we …
[HTML][HTML] Newly developed semi-synthetic chloroquine and hydroxychloroquine-phytochemical conjugates as prospective COVID-19 drug (s)
COVID-19 continues to be belligerent health threats nowadays and the Corona pandemic is
the global burden. Herein, two series of chloroquine (CQ) and hydroxychloroquine (HCQ) …
the global burden. Herein, two series of chloroquine (CQ) and hydroxychloroquine (HCQ) …
Repurposing nucleoside analogs for human coronaviruses
ABSTRACT Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed …
A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy
Coronaviruses are a group of enveloped viruses with non-segmented, single-stranded, and
positive-sense RNA genomes. It belongs to the 'Coronaviridae family', responsible for …
positive-sense RNA genomes. It belongs to the 'Coronaviridae family', responsible for …
Click chemistry can access unnatural N-acetylneuraminic acid–anchored β-cyclodextrin conjugates as potential anti-SARS-CoV-2 entry inhibitors
X Zhu, R Liu, Y Yi, L Hua, EV Tretyakova, Y Zhang… - Tetrahedron …, 2024 - Elsevier
Multivalent N-acetylneuraminic acid (Neu5Ac) derivatives can be used to block virus entry
into host cells by mimicking the natural receptors of the virus. However, the antiviral …
into host cells by mimicking the natural receptors of the virus. However, the antiviral …
Broad spectrum antiviral nucleosides—Our best hope for the future
KL Seley-Radtke, JE Thames, CD Waters III - Annual reports in medicinal …, 2021 - Elsevier
The current focus for many researchers has turned to the development of therapeutics that
have the potential for serving as broad-spectrum inhibitors that can target numerous viruses …
have the potential for serving as broad-spectrum inhibitors that can target numerous viruses …
New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2
At present therapeutic options for severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) are very limited. We designed and synthesized three sets of small molecules using …
CoV-2) are very limited. We designed and synthesized three sets of small molecules using …