4′-Modified nucleosides for antiviral drug discovery: achievements and perspectives
J Chang - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Modified nucleosides show therapeutic promise for antiviral therapies.
However, issues including the emergence of drug resistance, toxicity, and coinfections have …
However, issues including the emergence of drug resistance, toxicity, and coinfections have …
An update on pharmacological relevance and chemical synthesis of natural products and derivatives with anti SARS‐CoV‐2 activity
Natural products recognized traditionally as a vital source of active constituents in
pharmacotherapy. The COVID‐19 infection caused by severe acute respiratory syndrome …
pharmacotherapy. The COVID‐19 infection caused by severe acute respiratory syndrome …
Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: In silico and in vitro studies
In this study, a series of 1, 3, 4-oxadiazoles carrying the isatin moiety (IVa–g) as anti-SARS-
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …
Molnupiravir in COVID-19: A scoping review
S Kaore, S Atal - Current Drug Research Reviews Formerly …, 2022 - ingentaconnect.com
Background: COVID-19, first detected in Wuhan, China, has evolved into a lifethreatening
pandemic spread across six continents, with the global case count being more than 243 …
pandemic spread across six continents, with the global case count being more than 243 …
[HTML][HTML] Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques
K Rosenke, MC Lewis, F Feldmann, E Bohrnsen… - JCI insight, 2023 - ncbi.nlm.nih.gov
The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable
clinical severity and ability to escape preexisting immunity emphasizes the continued need …
clinical severity and ability to escape preexisting immunity emphasizes the continued need …
2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
K Uemura, H Nobori, A Sato, S Toba… - Proceedings of the …, 2023 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are causing
significant morbidity and mortality worldwide. Furthermore, over 1 million cases of newly …
significant morbidity and mortality worldwide. Furthermore, over 1 million cases of newly …
[HTML][HTML] Current findings regarding natural components with potential anti-2019-nCoV activity
J Zhou, J Huang - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
COVID-19, a novel coronavirus pneumonia (named by the World Health Organization,
WHO), has spread widely since the end of 2019. Research on synthetic drugs and vaccines …
WHO), has spread widely since the end of 2019. Research on synthetic drugs and vaccines …
[HTML][HTML] Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model
K Rosenke, A Okumura, MC Lewis, F Feldmann… - JCI insight, 2022 - ncbi.nlm.nih.gov
The recent emergence of the SARS-CoV-2 Omicron variant of concern (VOC), which
contains a heavily mutated spike protein capable of escaping preexisting immunity …
contains a heavily mutated spike protein capable of escaping preexisting immunity …
In Vitro and In Vivo Therapeutic Potential of 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea on Cells and K18-hACE2 Mice Infected with SARS-CoV-2
S Weiss, K Waidha, S Rajendran… - International Journal of …, 2023 - mdpi.com
We have previously published research on the anti-viral properties of an alkaloid mixture
extracted from Nuphar lutea, the major components of the partially purified mixture found by …
extracted from Nuphar lutea, the major components of the partially purified mixture found by …
Repurposing of Plant-based Antiviral Molecules for the Treatment of COVID-19
COVID-19, stemming from SARS-CoV-2, poses a formidable threat to global healthcare, with
a staggering 77 million confirmed cases and 690,067 deaths recorded till December 24 …
a staggering 77 million confirmed cases and 690,067 deaths recorded till December 24 …