In the context of accelerated aging of the population worldwide, frailty has emerged as one
of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome …

Background The relationship between age-related frailty and the underlying processes that
drive changes in health is currently unclear. Considered individually, most blood biomarkers …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

The knowledge about frailty is rapidly growing, and improved understanding of molecular
and physiological mechanisms involved in determining the increased vulnerability of frail …

The improvement of life quality and medical advances has resulted in increased life
expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is …

The term “frailty” is used to describe a subset of older adults who appear weaker and more
vulnerable than their age-matched counterparts, despite having similar comorbidities …

Frailty has been difficult to characterize because of its biologic complexity and because it
frequently overlaps with medical illness and disability. We recently validated a frailty …

Frailty is a common geriatric syndrome characterized by increased vulnerability and is
associated with adverse clinical events such as falls, hospitalization, and death. Early …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Ageing is accompanied with a decline in several physiological systems. Frailty is an age-
related syndrome correlated to the loss of homeostasis and increased vulnerability to …