Understanding the genetic underpinning of early human development is of great interest not
only for basic developmental and stem cell biology but also for regenerative medicine …

Establishing the different lineages of the early mammalian embryo takes place over several
days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Human embryo development occurs through a process that encompasses reprogramming,
sequential cleavage divisions and mitotic chromosome segregation and embryonic genome …

Within the mammalian class, formation of the blastocyst is morphologically highly conserved
among different species. The molecular and cellular events during preimplantation embryo …

Embryo development in mammals begins at fertilization with migration and fusion of the
gametic pronuclei and extensive genome-wide epigenetic remodeling. The hallmark of …

Early mammalian embryogenesis is currently the focus of intense interest because of the
potential of inner cell mass-derived embryonic stem cell lines in new therapeutic strategies …

After fertilization, mouse embryos go through preimplantation development to give rise to
blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell …

Studies of human embryos and fetuses have highlighted developmental differences
between humans and model organisms. In addition to describing the normal biology of our …