Big data and deep learning for RNA biology

H Hwang, H Jeon, N Yeo, D Baek - Experimental & Molecular Medicine, 2024 - nature.com
The exponential growth of big data in RNA biology (RB) has led to the development of deep
learning (DL) models that have driven crucial discoveries. As constantly evidenced by DL …

Deep learning in LncRNAome: contribution, challenges, and perspectives

T Alam, HRH Al-Absi, S Schmeier - Non-coding RNA, 2020 - mdpi.com
Long non-coding RNAs (lncRNA), the pervasively transcribed part of the mammalian
genome, have played a significant role in changing our protein-centric view of genomes …

Rnabench: A comprehensive library for in silico rna modelling

F Runge, K Farid, JKH Franke, F Hutter - bioRxiv, 2024 - biorxiv.org
RNA is a crucial regulator in living organisms and malfunctions can lead to severe diseases.
To explore RNA-based therapeutics and applications, computational structure prediction …

Rm-LR: a long-range-based deep learning model for predicting multiple types of RNA modifications

S Liang, Y Zhao, J Jin, J Qiao, D Wang, Y Wang… - Computers in Biology …, 2023 - Elsevier
Recent research has highlighted the pivotal role of RNA post-transcriptional modifications in
the regulation of RNA expression and function. Accurate identification of RNA modification …

Deep learning approaches for lncrna-mediated mechanisms: A comprehensive review of recent developments

Y Kim, M Lee - International journal of molecular sciences, 2023 - mdpi.com
This review paper provides an extensive analysis of the rapidly evolving convergence of
deep learning and long non-coding RNAs (lncRNAs). Considering the recent advancements …

Explainable deep learning for augmentation of small RNA expression profiles

J Fiosina, M Fiosins, S Bonn - Journal of Computational Biology, 2020 - liebertpub.com
The lack of well-structured metadata annotations complicates the reusability and
interpretation of the growing amount of publicly available RNA expression data. The …

Sequence similarity governs generalizability of de novo deep learning models for RNA secondary structure prediction

X Qiu - PLOS Computational Biology, 2023 - journals.plos.org
Making no use of physical laws or co-evolutionary information, de novo deep learning (DL)
models for RNA secondary structure prediction have achieved far superior performances …

A deep recurrent neural network discovers complex biological rules to decipher RNA protein-coding potential

ST Hill, R Kuintzle, A Teegarden, E Merrill III… - Nucleic acids …, 2018 - academic.oup.com
The current deluge of newly identified RNA transcripts presents a singular opportunity for
improved assessment of coding potential, a cornerstone of genome annotation, and for …

Recent advances of deep learning in bioinformatics and computational biology

B Tang, Z Pan, K Yin, A Khateeb - Frontiers in genetics, 2019 - frontiersin.org
Extracting inherent valuable knowledge from omics big data remains as a daunting problem
in bioinformatics and computational biology. Deep learning, as an emerging branch from …

Linc2function: A Comprehensive Pipeline and Webserver for Long Non-Coding RNA (lncRNA) Identification and Functional Predictions Using Deep Learning …

Y Ramakrishnaiah, AP Morris, J Dhaliwal, M Philip… - Epigenomes, 2023 - mdpi.com
Long non-coding RNAs (lncRNAs), comprising a significant portion of the human
transcriptome, serve as vital regulators of cellular processes and potential disease …