Little is known about the signal transduction pathways of TRK family receptors in
neuroblastoma (NB) cells. In this study, an NB cell line, designated MP‐N‐TS, was …

In neuroblastoma tumours, the expression of high levels of trk-A mRNA, which encodes the
high-affinity nerve growth factor (NGF) receptor, is associated with good prognosis …

Human neuroblastomas express the neurotrophin receptors trk-A and trk-B. Favourable
outcome is associated with expression of trk-A, while unfavourable, MYCN amplified …

There is considerable interest in the role of the TRK family of neuotrophin receptors in
regulating growth and differentiation in normal and neoplastic nerve cells. A neuroblastoma …

The Trk family consists of three receptor tyrosine kinases, each of which can be activated by
one or more of four neurotrophins—NGF, BDNF, NT3 and NT4. Neurotrophins mediate their …

To date more than twenty five different oncogenes have been identified in human
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …

Expression of trk family genes are prognostic indicators of neuroblastoma. However, the
functional role of neurotrophins and their receptors in neuroblastomas in vivo is still unclear …

Expression of different neurotrophin receptors of the tyrosine kinase (Trk) family plays an
important role in the biology and clinical behavior of neuroblastomas (NB). Observations …

Neuroblastoma, a childhood tumour of the sympathetic nervous system, may sometimes
regress spontaneously in infants, or progress to a poor clinical outcome despite intensive …

Neurotrophins are key signalling molecules in the development of the nervous system. They
elicit diverse cellular responses such as proliferation, differentiation, survival and apoptosis …