Over the past decade, we have witnessed an increasing number of large-scale studies that
have provided multi-omics data by high-throughput sequencing approaches. This has …

Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

Current cancer therapies target a limited set of tumor features, rather than considering the
tumor as a whole. Systems biology aims to reveal therapeutic targets associated with a …

The recent wide-spread adoption of single-cell profiling technologies has revealed that
individual cancers are not homogenous collections of deregulated cells, but instead …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …

Simple Summary Omics technologies and targeted drugs are revolutionizing the clinical
oncology landscape, portending the promise of precision oncology. However, our abilities to …

It is becoming evident that holistic perspectives toward cancer are crucial in deciphering the
overwhelming complexity of tumors. Single-layer analysis of genome-wide data has greatly …

Unexpected drug efficacy or resistance is poorly understood in cancers because of the lack
of systematic analyses of drug response profiles in cancer tissues of various genotypic …

The development of cost-effective technologies able to comprehensively assess DNA, RNA,
protein, and metabolites in patient tumors has fueled efforts to tailor medical care. Indeed …