Recent progress in our understanding of cancer mostly relies on the systematic profiling of
patient samples with high-throughput techniques like transcriptomics. With this approach …

Cancer is a complex and heterogeneous disease, demonstrating variations with respect to
tumor types and between individual tumors. This heterogeneity has complicated the search …

Current and emerging biomedical science efforts are driven by determining how to improve
clinical outcomes for patients, but the roadmap to achieve this goal has been controversial …

Highlights•Systems biology aids anti-cancer drug development for gastrointestinal
cancer.•Omics techniques can reveal potential signatures of chemotherapy responses at …

Despite advancements in treatment protocols, cancer is one of the leading cause of deaths
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …

An important challenge facing the field is how better to translate in vitro discoveries to the
clinic. Computational systems biology approaches that use omic data to predict biology …

With over two hundred types of cancer diagnosed to date, researchers the world over have
been forced to rapidly update their understanding of the biology of cancer. In fact, only the …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

A complex framework of interacting partners including genetic, proteomic, and metabolic
networks that cooperate to mediate specific functional phenotypes drives human biological …

Although cancer heterogeneity, even within individual tumors with different treatment
responses of subcloncal cells populations, suggests the need for personalized medicine …