Phenotypic heterogeneity within malignant cells of a tumor is emerging as a key property of
tumorigenesis. Recent work using single-cell transcriptomics has led to the identification of …

Precision medicine is an approach that takes into account the influence of individuals'
genes, environment, and lifestyle exposures to tailor interventions. Here, we describe the …

Although cancer research is progressing at an exponential rate, translating this knowledge
to develop better cancer drugs and more effectively match drugs to patients is lagging …

Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …

There is an urgent need to elicit and validate highly efficacious targets for combinatorial
intervention from large scale ongoing molecular characterization efforts of tumors. We …

The future of cancer treatment lies in personalized strategies designed to specifically target
tumorigenic cell populations present in an individual. Although recent advances in directed …

Background Tumors are complex multifaceted ecosystems composed of malignant cells
surrounded by a heterogeneous mixture of cell types. During oncogenesis, different …

Tumor heterogeneity has been identified at various-omic levels. The tumor genome,
transcriptome, proteome, and phenome can vary widely across cells in patient tumors and …

The acquisition of cancer hallmarks requires molecular alterations at multiple levels
including genome, epigenome, transcriptome, proteome, and metabolome. In the past …

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ
between individual patients and even among individual tumor regions. In recent years, large …