The acquisition of cancer hallmarks requires molecular alterations at multiple levels
including genome, epigenome, transcriptome, proteome, and metabolome. In the past …

Background High throughput technologies have been used to profile genes in multiple
different dimensions, such as genetic variation, copy number, gene and protein expression …

Leveraging insights from genomic studies of patient tumors is limited by the discordance
between these tumors and the cell line models used for functional studies. We integrate …

Author Summary Cancer is now increasingly studied from the perspective of dysregulated
pathways, rather than as a disease resulting from mutations of individual genes. A pathway …

Despite identical genetic constitution, a cancer cell population can exhibit phenotypic
variations termed as non-genetic/non-mutational heterogeneity. Such heterogeneity–a …

Cancer-specific perturbations of signaling, metabolism, and epigenetics can be a cause
and/or consequence of malignant transformation. Evidence indicates that these regulatory …

Precision cancer medicine is based on the ability to predict the dependencies of a given
tumor from its molecular makeup. These dependencies can be exploited with targeted …

Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic
alterations. Often, these changes underlie cancer development, progression, and drug …

Cancer cell lines have been widely used for decades to study biological processes driving
cancer development, and to identify biomarkers of response to therapeutic agents …

Background Drug resistance continues to be a major limiting factor across diverse anti-
cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in …