The vast number of genomic and molecular alterations in cancer pose a substantial
challenge to uncovering the mechanisms of tumorigenesis and identifying therapeutic …

Prospective molecular characterization of cancer has enabled physicians to define the
genomic changes of each patient's tumor in real time and select personalized therapies …

Background Precision oncology is a clinical approach aimed towards tailoring treatment
strategies for patients based on the genetic profile of each patient's cancer. The integration …

Background and purpose Predicting the efficacy of anticancer therapy is the holy grail of
drug development and treatment selection in the clinic. To achieve this goal, scientists …

High-throughput sequencing can be used to measure changes in tumor composition across
space and time. Specifically, comparisons of pre-and post-treatment samples can reveal the …

Cancer is a complex disease at many different levels. The molecular phenomenology of
cancer is also quite rich. The mutational and genomic origins of cancer and their …

Systematic studies of cancer genomes have provided unprecedented insights into the
molecular nature of cancer. Using this information to guide the development and application …

Cancer progresses due to changes in the dynamic interactions of multidimensional factors
associated with gene mutations. Cancer research has actively adopted computational …

Recent discoveries of genomic alterations that underlie and promote the malignant
phenotype, together with an expanded repertoire of targeted agents, have provided many …

Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …