With advances in technology and bioinformatics, we are now positioned to view and
manage cancer through an evolutionary lens. This perspective is critical as our appreciation …

Tumor heterogeneity, a hallmark of cancer, impairs the efficacy of cancer therapy and drives
tumor progression. Exploring inter-and intra-tumoral heterogeneity not only provides insights …

While cost-effective high-throughput technologies provide an increasing amount of data, the
analyses of single layers of data seldom provide causal relations. Multi-omics data …

Disruptive innovations in medicine are game-changing in nature and bring about radical
shifts in the way we understand human diseases, their treatment, and/or prevention. Yet …

Recent advances in sequencing and biotechnological methodologies have led to the
generation of large volumes of molecular data of different omics layers, such as genomics …

Abstract Systems biology approaches that embrace the complexity of cancer are starting to
gain traction in the development of new anticancer therapeutic strategies. In this review we …

Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and
cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer …

The main conclusion is that systems biology approaches can indeed advance cancer
research, having already proved successful in a very wide variety of cancer‐related areas …

Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Characterizing the complex interplay of cellular processes in cancer would enable the
discovery of key mechanisms underlying its development and progression. Published …