Advancements in next-generation sequencing and other-omics technologies are
accelerating the detailed molecular characterization of individual patient tumors, and driving …

With the genetic portraits of all major human malignancies now available, we next face the
challenge of characterizing the function of mutated genes, their downstream targets …

The systematic sequencing of the cancer genome has led to the identification of numerous
genetic alterations in cancer. However, a deeper understanding of the functional …

Precision medicine has changed thinking in cancer therapy, highlighting a better
understanding of the individual clinical interventions. But what role do the drivers and …

Constructing, evaluating, and interpreting gene networks generally sits within the broader
field of systems biology, which continues to emerge rapidly, particular with respect to its …

The unprecedented amount of data produced with high-throughput experimentation forces
biologists to employ mathematical representation and computation to glean meaningful …

Intratumor heterogeneity is a common characteristic across diverse cancer types and
presents challenges to current standards of treatment. Advancements in high-throughput …

Background Personalized therapy provides the best outcome of cancer care and its
implementation in the clinic has been greatly facilitated by recent convergence of enormous …

Heterogeneity in tumors is recognized as a key contributor to drug resistance and spread of
advanced disease, but deep characterization of genetic variation within tumors has only …

Cancer is a disease of gene dysregulation, where cells acquire genetic alterations that drive
aberrant signaling. These alterations adversely impact transcriptional programs and cause …