Aim: Accumulating evidence links epigenetic age to diseases and age-related conditions,
but little is known about its association with multiple sclerosis (MS). Materials & methods: We …

Background Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of
the central nervous system (CNS) characterized by irreversible disability at later progressive …

Background and Objectives In multiple sclerosis (MS), accelerated aging of the immune
system (immunosenescence) may be associated with disease onset or drive progression …

Epigenetic mechanisms can regulate how DNA is expressed independently of sequence
and are known to be associated with various diseases. Among those epigenetic …

Background The epigenetic clock, in particular epigenetic pre-aging quantified by the so-
called DNA methylation age acceleration, has recently been suggested to closely correlate …

Aims Epigenetic clocks are widely applied as surrogates for biological age in different
tissues and/or diseases, including several neurodegenerative diseases. Despite white …

Background A compelling body of evidence implicates cigarette smoking and lung
inflammation in Multiple Sclerosis (MS) susceptibility and progression. Previous studies …

Background: There is strong evidence that epigenetic age acceleration is associated with
increased risk of later-life diseases and all-cause mortality. However, there is currently …

Background The variation in multiple sclerosis (MS) disease severity is incompletely
explained by genetics, suggesting genetic and environmental interactions are involved …

Background Biological ageing is one of the principal risk factors for neurodegenerative
diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as …