Upon recognition of specific molecular patterns on microbes, host cells trigger an innate
immune response, which culminates in the production of type I interferons, proinflammatory …

The current view of cytoplasmic RNA-mediated innate immune signaling involves the
differential activation of the RNA helicases retinoic acid-inducible gene 1 (RIG-I), melanoma …

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses
against viral infections that serve to limit virus replication and to stimulate adaptive immunity …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

The recent, rapid progress in our understanding of cytoplasmic RNA-mediated antiviral
innate immune signaling was initiated by the discovery of retinoic acid-inducible gene I (RIG …

During virus infection, multiple immune signaling pathways are triggered, both within the
host cell and bystander cells of an infected tissue. These pathways act in concert to mediate …

Highlights•A balance of phosphorylation and K63-linked ubiquitination regulates RIG-I.•RIG-
I and MAVS functions are modulated by alternative splicing and translation.•Subcellular …

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen
sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect …

RIG-I and MDA5 are cytoplasmic viral RNA sensors and are essential for antiviral innate
immune responses, such as type I interferon production. Post-translational modification is …

Most organisms rely on innate immune receptors to recognize conserved molecular
structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5 …