The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

G Xu, F Qi, H Li, Q Yang, H Wang, X Wang, X Liu… - Cell discovery, 2020 - nature.com
Understanding the mechanism that leads to immune dysfunction in severe coronavirus
disease 2019 (COVID-19) is crucial for the development of effective treatment. Here, using …

Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations

B Kratzer, D Trapin, P Ettel, U Körmöczi, A Rottal… - Allergy, 2021 - Wiley Online Library
Background SARS‐CoV‐2 has triggered a pandemic that is now claiming many lives.
Several studies have investigated cellular immune responses in COVID‐19‐infected …

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

A Mazzoni, L Salvati, L Maggi… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Coronavirus disease 19 (COVID-19) is an emerging infectious disease
caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen …

COVID-19 as an acute inflammatory disease

RH Manjili, M Zarei, M Habibi… - The journal of immunology, 2020 - journals.aai.org
Abstract The 2019 coronavirus disease (COVID-19) pandemic caused by the virus severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created an unprecedented …

[HTML][HTML] COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis

KM Sohn, SG Lee, HJ Kim, S Cheon… - Journal of Korean …, 2020 - synapse.koreamed.org
Background Observational studies of the ongoing coronavirus disease 2019 (COVID-19)
outbreak suggest that a 'cytokine storm'is involved in the pathogenesis of severe illness …

An enlightening role for cytokine storm in coronavirus infection

Z Zhao, Y Wei, C Tao - Clinical Immunology, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Wuhan,
China has dispersed rapidly worldwide. Although most patients present with mild fever …

Hyperinflammatory state and low T1 adaptive immune response in severe and critical acute COVID-19 patients

M Garcia-Gasalla, M Berman-Riu, J Pons… - Frontiers in …, 2022 - frontiersin.org
Background A better understanding of COVID-19 immunopathology is needed to identify the
most vulnerable patients and improve treatment options. Objective We aimed to identify …

Immunouniverse of SARS-CoV-2

D Jiménez, M Torres Arias - Immunological Medicine, 2022 - Taylor & Francis
SARS-CoV-2 virus has become a global health problem that has caused millions of deaths
worldwide. The infection can present with multiple clinical features ranging from …

The pathogenesis of coronavirus-19 disease

AC Borczuk, RK Yantiss - Journal of biomedical science, 2022 - Springer
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …

Deciphering SARS-CoV-2 virologic and immunologic features

G Lebeau, D Vagner, E Frumence, F Ah-Pine… - International journal of …, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and its associated
pathology, COVID-19, have been of particular concerns these last months due to the …