Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission

MW Russell, J Mestecky - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on
reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact …

[HTML][HTML] NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

M Guebre-Xabier, N Patel, JH Tian, B Zhou… - Vaccine, 2020 - Elsevier
There is an urgent need for a safe and protective vaccine to control the global spread of
SARS-CoV-2 and prevent COVID-19. Here, we report the immunogenicity and protective …

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

MJ Smit, AF Sander, MBPA Ariaans… - The Lancet …, 2023 - thelancet.com
Background Capsid virus-like particles (cVLP) have proven safe and immunogenic and can
be a versatile platform to counter pandemics. We aimed to clinically test a modular cVLP …

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial

R Ella, KM Vadrevu, H Jogdand, S Prasad… - The Lancet Infectious …, 2021 - thelancet.com
Background To mitigate the effects of COVID-19, a vaccine is urgently needed. BBV152 is a
whole-virion inactivated SARS-CoV-2 vaccine formulated with a toll-like receptor 7/8 agonist …

[HTML][HTML] Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

L Azzi, D Dalla Gasperina, G Veronesi, M Shallak… - …, 2022 - thelancet.com
Background Although the BNT162b2 COVID-19 vaccine is known to induce IgG neutralizing
antibodies in serum protecting against COVID-19, it has not been studied in detail whether it …

COVID-19 vaccine trials in Africa

M Makoni - The Lancet Respiratory Medicine, 2020 - thelancet.com
On Aug 17, 2020, screening began for participants to enrol in the midstage study of an
experimental COVID-19 vaccine by Novavax, a US drug developer of next-generation …

Immunogenicity of the Ad26. COV2. S Vaccine for COVID-19

KE Stephenson, M Le Gars, J Sadoff, AM de Groot… - Jama, 2021 - jamanetwork.com
Importance Control of the global COVID-19 pandemic will require the development and
deployment of safe and effective vaccines. Objective To evaluate the immunogenicity of the …

Nasal and salivary mucosal humoral immune response elicited by mRNA BNT162b2 COVID-19 vaccine compared to SARS-CoV-2 natural infection

M Guerrieri, B Francavilla, D Fiorelli, M Nuccetelli… - Vaccines, 2021 - mdpi.com
SARS-CoV-2 antibody assays are crucial in managing the COVID-19 pandemic. Approved
mRNA COVID-19 vaccines are well known to induce a serum antibody responses against …

Humoral immune response of BBIBP COVID‐19 vaccination before and after the booster immunization

ZJ Cheng, H Huang, P Zheng, M Xue, J Ma, Z Zhan… - Allergy, 2022 - Wiley Online Library
Abstract Background The inactivated Sinopharm/BBIBP COVID‐19 vaccine has been widely
used in the world and has joined the COVAX vaccine supply program for developing …

Evaluation of the systemic and mucosal immune response induced by COVID-19 and the BNT162b2 mRNA vaccine for SARS-CoV-2

O Nickel, A Rockstroh, J Wolf, S Landgraf, S Kalbitz… - PLoS one, 2022 - journals.plos.org
Background The currently used SARS-CoV-2 mRNA vaccines have proven to induce a
strong and protective immune response. However, functional relevance of vaccine …