Correcting for population stratification reduces false positive and false negative results in joint analyses of host and pathogen genomes
Studies of host genetic determinants of pathogen sequence variations can identify sites of
genomic conflicts, by highlighting variants that are implicated in immune response on the …
genomic conflicts, by highlighting variants that are implicated in immune response on the …
Mapping the drivers of within-host pathogen evolution using massive data sets
Differences among hosts, resulting from genetic variation in the immune system or
heterogeneity in drug treatment, can impact within-host pathogen evolution. Genetic …
heterogeneity in drug treatment, can impact within-host pathogen evolution. Genetic …
Pathogen exposure misclassification can bias association signals in GWAS of infectious diseases when using population-based common control subjects
Genome-wide association studies (GWASs) have been performed to identify host genetic
factors for a range of phenotypes, including for infectious diseases. The use of population …
factors for a range of phenotypes, including for infectious diseases. The use of population …
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
HIV-1 sequence diversity is affected by selection pressures arising from host genomic
factors. Using paired human and viral data from 1071 individuals, we ran> 3000 genome …
factors. Using paired human and viral data from 1071 individuals, we ran> 3000 genome …
Exploring the interactions between the human and viral genomes
J Fellay, V Pedergnana - Human genetics, 2020 - Springer
Over the last decade, genome-wide association studies led to major advances in identifying
human genetic variants associated with infectious disease susceptibility. On the pathogen …
human genetic variants associated with infectious disease susceptibility. On the pathogen …
Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility
Infectious disease has shaped the natural genetic diversity of humans throughout the world.
A new approach to capture positive selection driven by pathogens would provide …
A new approach to capture positive selection driven by pathogens would provide …
Genome-wide association studies of viral infections—A short guide to a successful experimental and statistical analysis
A Butković, SF Elena - Frontiers in Systems Biology, 2022 - frontiersin.org
Genome-wide association studies (GWAS) have been gaining popularity over the last
decade as they provide new insights into the genetic architecture of many disease-related …
decade as they provide new insights into the genetic architecture of many disease-related …
Shared pathways to infectious disease susceptibility?
CC Khor, ML Hibberd - Genome medicine, 2010 - Springer
The recent advent of genomic approaches for association testing is starting to enable a more
comprehensive understanding of the role of human immune response in determining …
comprehensive understanding of the role of human immune response in determining …
Founder effects in the assessment of HIV polymorphisms and HLA allele associations
Escape from T cell–mediated immune responses affects the ongoing evolution of rapidly
evolving viruses such as HIV. By applying statistical approaches that account for …
evolving viruses such as HIV. By applying statistical approaches that account for …
Human genome variability, natural selection and infectious diseases
M Fumagalli, M Sironi - Current opinion in immunology, 2014 - Elsevier
Highlights•Demographic history and natural selection shaped human genome
diversity.•Infections represented a major environmental selective pressure for human …
diversity.•Infections represented a major environmental selective pressure for human …