Genetic associations with suicide attempt severity and genetic overlap with major depression

DF Levey, R Polimanti, Z Cheng, H Zhou… - Translational …, 2019 - nature.com
Abstract In 2015,~ 800,000 people died by suicide worldwide. For every death by suicide
there are as many as 25 suicide attempts, which can result in serious injury even when not …

GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores

N Mullins, TB Bigdeli, AD Børglum… - American journal of …, 2019 - Am Psychiatric Assoc
Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is …

[HTML][HTML] Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors

N Mullins, JE Kang, AI Campos, JRI Coleman… - Biological …, 2022 - Elsevier
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …

Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study

A Erlangsen, V Appadurai, Y Wang, G Turecki… - Molecular …, 2020 - nature.com
Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular
studies are needed to identify loci accounting for genetic heritability. We conducted a …

GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors

AR Docherty, N Mullins… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-
scale genome-wide association studies (GWASs) recently discovered and cross-validated …

Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide

DM Ruderfer, CG Walsh, MW Aguirre, Y Tanigawa… - Molecular …, 2020 - nature.com
Suicide accounts for nearly 800,000 deaths per year worldwide with rates of both deaths
and attempts rising. Family studies have estimated substantial heritability of suicidal …

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome‐wide association and polygenic scoring study

N Mullins, N Perroud, R Uher, AW Butler… - American Journal of …, 2014 - Wiley Online Library
Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is
independent of other psychiatric disorders. Genome‐wide association studies (GWAS) on …

Genome-wide association study of suicide death and polygenic prediction of clinical antecedents

AR Docherty, AA Shabalin, E DiBlasi… - American journal of …, 2020 - Am Psychiatric Assoc
Objective: Death by suicide is a highly preventable yet growing worldwide health crisis. To
date, there has been a lack of adequately powered genomic studies of suicide, with no …

Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population

I Otsuka, M Akiyama, O Shirakawa, S Okazaki… - …, 2019 - nature.com
Suicide is a significant public health problem worldwide, and several Asian countries
including Japan have relatively high suicide rates on a world scale. Twin, family, and …

A pilot genome wide association and gene expression array study of suicide with and without major depression

H Galfalvy, G Zalsman, YY Huang… - The world journal of …, 2013 - Taylor & Francis
Objectives. Suicide is partly heritable but the responsible genes have not been identified.
We conducted a gene-centric, low coverage single nucleotide polymorphism (SNP) pilot …