One of the major problems with bone tissue engineering is the development of a rapid
vascularization after implantation to supply the growing osteoblast cells with the nutrients to …

Bone tissue is a highly vascularized and dynamic system with a complex construction. In
order to develop a construct for implant purposes in bone tissue engineering, a proper …

Cellular strategies play an important role in bone tissue engineering and regenerative
medicine (BTE/RM). Variability in cell culture procedures (eg, cell types, cell isolation and …

This review summarizes recent efforts to create vascularized bone tissue in vitro and in vivo
through the use of cell-based therapy approaches. The treatment of large and recalcitrant …

The lack of a functional vascular supply has been identified as a major challenge limiting the
clinical introduction of stem cell-based bone tissue engineering (BTE) for the repair of large …

Co-culture of bone forming cells and endothelial cells to induce pre-vascularization is one of
the strategies used to solve the insufficient vascularization problem in bone tissue …

In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered
bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen …

Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge
limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …

The generation of functional, vascularized tissues is a key challenge for the field of tissue
engineering. Before clinical implantations of such tissue engineered bone constructs can …

Bone tissue engineering (BTE) aims to improve the healing of bone fractures using scaffolds
that mimic the native extracellular matrix. For successful bone regeneration, scaffolds should …