The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

ÁC Roman, JM Carvajal-Gonzalez, JM Merino… - Pharmacology & …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology

C Esser, A Rannug - Pharmacological reviews, 2015 - ASPET
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to
the Per-ARNT-Sim–basic helix-loop-helix protein family. AhR translocates into the nucleus …

Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

NC Sondermann, S Faßbender, F Hartung… - Biochemical …, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

Aryl hydrocarbon receptor: a new player of pathogenesis and therapy in cardiovascular diseases

T Yi, J Wang, K Zhu, Y Tang, S Huang… - BioMed research …, 2018 - Wiley Online Library
The aryl hydrocarbon receptor (AhR) is a DNA binding protein that acts as a nuclear
receptor mediating xenobiotic metabolism and environmental responses. Owing to the …

Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths

L Sládeková, S Mani, Z Dvořák - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription
factors family. This receptor has a central role in determining host physiology and a variety of …

The complex biology of aryl hydrocarbon receptor activation in cancer and beyond

CA Opitz, P Holfelder, MT Prentzell, S Trump - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

E Guyot, A Chevallier, R Barouki, X Coumoul - Drug discovery today, 2013 - Elsevier
The aryl hydrocarbon receptor (AhR) is a transcription factor which is activated by diverse
compounds and regulates the expression of xenobiotic metabolism genes. Recent studies …

[HTML][HTML] From nucleus to organs: insights of aryl hydrocarbon receptor molecular mechanisms

CM Rejano-Gordillo, B Marín-Díaz… - International Journal of …, 2022 - mdpi.com
The aryl hydrocarbon receptor (AHR) is a markedly established regulator of a plethora of
cellular and molecular processes. Its initial role in the detoxification of xenobiotic …

[HTML][HTML] Aryl hydrocarbon receptor: From homeostasis to tumor progression

C Rejano-Gordillo, A Ordiales-Talavero… - Frontiers in Cell and …, 2022 - frontiersin.org
Transcription factor aryl hydrocarbon receptor (AHR) has emerged as one of the main
regulators involved both in different homeostatic cell functions and tumor progression. Being …

[HTML][HTML] The landscape of AhR regulators and coregulators to fine-tune AhR functions

M Gargaro, G Scalisi, G Manni, G Mondanelli… - International Journal of …, 2021 - mdpi.com
The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates
numerous cellular responses. Originally investigated in toxicology because of its ability to …