Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level

Y Li, S Sacchi, L Pollegioni, AC Basu, JT Coyle… - Nature …, 2013 - nature.com
Mechanisms of N-methyl-d-aspartate receptor-dependent synaptic plasticity contribute to the
acquisition and retention of conditioned fear memory. However, synaptic rules which may …

Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of the lateral amygdala

MG Weisskopf, JE LeDoux - Journal of neurophysiology, 1999 - journals.physiology.org
Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of
the lateral amygdala. Fear conditioning involves the transmission of sensory stimuli to the …

NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala

KA Goosens, S Maren - European Journal of Neuroscience, 2004 - Wiley Online Library
We examined the contribution of N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) to the
acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using …

NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory

F Zinebi, J Xie, J Liu, RT Russell… - Journal of …, 2003 - Soc Neuroscience
The amygdala plays a critical role in fear conditioning, a model of emotional learning and
cue-induced anxiety. In the lateral amygdala, fear conditioning is associated with an …

Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala

F Sotres-Bayon, DEA Bush, JE LeDoux - Neuropsychopharmacology, 2007 - nature.com
N-methyl-D-aspartate receptors (NMDARs) contribute to synaptic plasticity underlying
learning in a variety of brain systems. Fear extinction, which involves learning to suppress …

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans

R Kalisch, B Holt, P Petrovic, B De Martino… - Cerebral …, 2009 - academic.oup.com
Animal research suggests that the consolidation of fear and extinction memories depends
on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and …

N-Methyl D-aspartate receptor subunit signaling in fear extinction

J Radulovic, LY Ren, C Gao - Psychopharmacology, 2019 - Springer
N-Methyl D-aspartate receptors (NMDAR) are central mediators of glutamate actions
underlying learning and memory processes including those required for extinction of fear …

N-Methyl-D-aspartate receptor antagonism blocks contextual fear conditioning and differentially regulates early growth response-1 messenger RNA expression in the …

S Malkani, JB Rosen - Neuroscience, 2001 - Elsevier
N-Methyl-d-aspartate receptors in the amygdala are known to be crucial for the learning of
conditioned fear, although the molecular cascades that N-methyl-d-aspartate receptors …

D-serine enhances fear extinction by increasing GluA2-containing AMPA receptor endocytosis

Y Bai, L Zhou, X Wu, Z Dong - Behavioural brain research, 2014 - Elsevier
Activation of the N-methyl-d-aspartate receptor (NMDAR) glycine site has been shown to
enhance memory extinction in physiological and pathological conditions. In the current …

Astrocytic NMDA receptors in the basolateral amygdala contribute to facilitation of fear extinction

GP Shelkar, J Liu, SM Dravid - International Journal of …, 2021 - academic.oup.com
Background Enhancement of N-methyl-D-aspartate (NMDA) receptor function using glycine-
site agonist D-cycloserine is known to facilitate fear extinction, providing a means to …