Skeletal loading is an important physiological regulator of bone mass. Theoretically,
mechanical forces or administration of drugs that activate bone mechanosensors would be a …

This chapter reviews the state of knowledge with respect to skeletal mechanobiology. Forms
of tissue-level mechanical stimulation are first described, including electromagnetic fields …

The conceptual model of the mechanostat proposed by Harold Frost in 1983 is among the
most significant contributions to musculoskeletal research today. This model states that bone …

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Bone demonstrates a remarkable ability to renew itself, adapt its architecture, and repair
fractures to maintain strength throughout life. Mechanobiology, the study of how external …

The molecular mechanisms that transduce the osteoblast response to physical forces in the
bone microenvironment are poorly understood. Here, we used genetic and pharmacological …

Osteoblasts are key components of the bone multicellular unit and have a seminal role in
bone remodeling, which is an essential function for the maintenance of the structural …

The skeleton has the ability to perfectly adapt to external forces of the operating
environment, by altering its morphology and metabolism in order to meet different needs …

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Proper development of the skeleton in utero and during growth requires mechanical
stimulation. Loading results in adaptive changes in bone that strengthen bone structure …