The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19

MS Basile, E Cavalli, J McCubrey… - Drug discovery today, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has emerged as a serious threat to global
health. The disregulation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian …

PI3K/Akt/mTOR pathway: a potential target for anti-SARS-CoV-2 therapy

S Fattahi, Z Khalifehzadeh-Esfahani… - Immunologic …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). A single-stranded RNA virus from a β …

Targeting the PI3K/Akt/mTOR pathway: A therapeutic strategy in COVID-19 patients

R Abu-Eid, FJ Ward - Immunology letters, 2021 - Elsevier
Some COVID-19 patients suffer complications from anti-viral immune responses which can
lead to both a dangerous cytokine storm and development of blood-borne factors that render …

[HTML][HTML] Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19

F Sun, C Mu, HF Kwok, J Xu, Y Wu, W Liu… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has led to more than 150 million infections …

PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19

MR Khezri - Human Cell, 2021 - Springer
To the editor Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), poses a major challenge to the world's healthcare …

An open question: is it rational to inhibit the mTor-dependent pathway as COVID-19 therapy?

G Terrazzano, V Rubino, AT Palatucci… - Frontiers in …, 2020 - frontiersin.org
In December 2019, a novel coronavirus infection appeared in China (Wuhan City and Hubei
Province), causing the first cases of abnormal severe pneumonia. Since then, the SARS …

Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

S Appelberg, S Gupta… - Emerging microbes & …, 2020 - Taylor & Francis
How severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections engage
cellular host pathways and innate immunity in infected cells remains largely elusive. We …

SARS-CoV-2 infection triggers phosphorylation: potential target for anti-COVID-19 therapeutics

B Chatterjee, SS Thakur - Frontiers in immunology, 2022 - frontiersin.org
The SARS-CoV-2 infection triggers host kinases and is responsible for heavy
phosphorylation in the host and also in the virus. Notably, phosphorylations in virus were …

[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection

M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinase

CK Yuen, WM Wong, LF Mak, X Wang… - Journal of medical …, 2021 - Wiley Online Library
The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
emerged at the end of 2019 and caused the coronavirus disease 19 (COVID‐19) pandemic …