Objective Concentrations of circulating sex hormones have been associated with a variety of
diseases in women and are strongly influenced by menopausal status. We investigated the …

Genome-wide association studies (GWAS) have successfully identified common genetic
variants that contribute to breast cancer risk. Discovering additional variants has become …

Twin studies suggest a heritable component to circulating sex steroid hormones and sex
hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort …

Genetic factors contribute strongly to sex hormone levels, yet knowledge of the regulatory
mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified …

Background Postmenopausal hormone therapy (HT) influences endogenous hormone
concentrations and increases the risk of breast cancer. Gene expression profiling may …

Background Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been
associated with many diseases in observational studies; however, the causality of …

Even though the levels of circulating sex steroid hormones are to a large extent heritable,
their genetic determinants are largely unknown. With the advent of genome-wide …

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and
biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has …

We synthesized findings relating health outcomes and genetic variants of the sex steroid
hormone pathway in women from the Study of Women's Health Across the Nation (SWAN) …

Background Sex hormones and gonadotropins exert a wide variety of effects in
physiological and pathological processes. Accumulated evidence shows a strong heritable …