Whatever their differentiation status, human progenitor derived–or mature–endothelial cells induce osteoblastic differentiation of bone marrow stromal cells

NB Thébaud, R Siadous, R Bareille… - Journal of tissue …, 2012 - Wiley Online Library
Association of the bone‐forming osteoblasts (OBs) and vascular endothelial cells (ECs) into
a biomaterial composite provides a live bone graft substitute that can repair the bone defect …

Contribution of endothelial cells to human bone-derived cells expansion in coculture

J Leszczynska, B Zyzynska-Granica… - … Engineering Part A, 2013 - liebertpub.com
Creating a functional vascularized bone tissue remains one of the main goals of bone tissue
engineering. Recently, a growing interest in the crosstalk between endothelial cells (EC) …

Endothelial Progenitor Cell Fraction Contained in Bone Marrow‐Derived Mesenchymal Stem Cell Populations Impairs Osteogenic Differentiation

F Duttenhoefer, R Lara de Freitas… - BioMed research …, 2015 - Wiley Online Library
In bone tissue engineering (TE) endothelial cell‐osteoblast cocultures are known to induce
synergies of cell differentiation and activity. Bone marrow mononucleated cells (BMCs) are a …

Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures

I Pennings, LA van Dijk, J van Huuksloot… - Journal of tissue …, 2019 - Wiley Online Library
To introduce a functional vascular network into tissue‐engineered bone equivalents, human
endothelial colony forming cells (ECFCs) and multipotent mesenchymal stromal cells …

Effects of endothelial cells on proliferation and survival of human mesenchymal stem cells and primary osteoblasts

D Steiner, F Lampert, GB Stark… - Journal of Orthopaedic …, 2012 - Wiley Online Library
Angiogenesis is a fundamental process in bone formation, remodeling, and regeneration.
Moreover, for the regeneration of bone in tissue engineering applications, it is essential to …

The role of endothelial progenitor cells in prevascularized bone tissue engineering: development of heterogeneous constructs

NE Fedorovich, RT Haverslag, WJA Dhert… - … Engineering Part A, 2010 - liebertpub.com
In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

Human umbilical vein endothelial cells (HUVECs) co-culture with osteogenic cells: from molecular communication to engineering prevascularised bone grafts

I Kocherova, A Bryja, P Mozdziak… - Journal of clinical …, 2019 - mdpi.com
The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …

Endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) in bone healing

NC Keramaris, S Kaptanis, H Lucy Moss… - Current stem cell …, 2012 - ingentaconnect.com
Fracture healing is a complex physiological process. Local vascularity at the site of the
fracture has been established as one of the most important factors influencing the healing …

Endothelial cell modulation of bone marrow stromal cell osteogenic potential

D Kaigler, PH Krebsbach, ER West, K Horger… - The FASEB …, 2005 - Wiley Online Library
In the context of bone development and regeneration, the intimate association of the
vascular endothelium with osteogenic cells suggests that endothelial cells (ECs) may …

Human Endothelial‐Like Differentiated Precursor Cells Maintain Their Endothelial Characteristics When Cocultured with Mesenchymal Stem Cell and Seeded onto …

D Henrich, K Wilhelm, J Warzecha… - Mediators of …, 2013 - Wiley Online Library
Introduction. Cancellous bone is frequently used for filling bone defects in a clinical setting. It
provides favourable conditions for regenerative cells such as MSC and early EPC. The …