Background The histone variant H3. 3 plays a critical role in maintaining the pluripotency of
embryonic stem cells (ESCs) by regulating gene expression programs important for lineage …

Histone variants and their chaperones are key regulators of eukaryotic transcription, and are
critical for normal development. The histone variant H3. 3 has been shown to play important …

Background The histone variant H3. 3 is enriched at active regulatory elements such as
promoters and enhancers in mammalian genomes. These regions are highly accessible …

H1 linker histones facilitate higher-order chromatin folding and are essential for mammalian
development. To achieve high-resolution mapping of H1 variants H1d and H1c in embryonic …

Heterochromatin, a densely packed chromatin state that is transcriptionally silent, is a critical
regulator of gene expression. However, it is unclear how the repressive histone modification …

During metazoan development, the marked change in developmental potential from the
parental germline to the embryo raises an important question regarding how the next life …

Little is known about the telomere chromatin dynamics of embryonic stem (ES) cell. Here, we
demonstrate localization of histone H3. 3 at interphase telomeres and enrichment of Ser31 …

Pluripotent embryonic stem cells (ESCs) are known to possess a relatively open chromatin
structure; yet, despite efforts to characterize the chromatin signatures of ESCs, the role of …

H3. 3 is a highly conserved nonreplicative histone variant. H3. 3 is enriched in promoters
and enhancers of active genes, but it is also found within suppressed heterochromatin …

Background Linker histone H1 is a core chromatin component that binds to nucleosome
core particles and the linker DNA between nucleosomes. It has been implicated in chromatin …