Virtual screening and hit selection of natural compounds as acetylcholinesterase inhibitors
M Atanasova, I Dimitrov, S Ivanov, B Georgiev… - Molecules, 2022 - mdpi.com
Acetylcholinesterase (AChE) is one of the classical targets in the treatment of Alzheimer's
disease (AD). Inhibition of AChE slows down the hydrolysis of acetycholine and increases …
disease (AD). Inhibition of AChE slows down the hydrolysis of acetycholine and increases …
A computational approach to identify phytochemicals as potential inhibitor of acetylcholinesterase: Molecular docking, ADME profiling and molecular dynamics …
Inhibition of acetylcholinesterase (AChE) is a crucial target in the treatment of Alzheimer's
disease (AD). Common anti-acetylcholinesterase drugs such as Galantamine, Rivastigmine …
disease (AD). Common anti-acetylcholinesterase drugs such as Galantamine, Rivastigmine …
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques
Y Chen, L Fang, S Peng, H Liao, J Lehmann… - Bioorganic & medicinal …, 2012 - Elsevier
Acetylcholinesterase (AChE) is considered to be one of the most important targets for the
treatment of Alzheimer's disease (AD). Previously our group has reported a series of tacrine …
treatment of Alzheimer's disease (AD). Previously our group has reported a series of tacrine …
Molecular evaluation of herbal compounds as potent inhibitors of acetylcholinesterase for the treatment of Alzheimer's disease
YX Chen, GZ Li, B Zhang… - Molecular Medicine …, 2016 - spandidos-publications.com
Alzheimer's disease (AD) is a progressive disease and the predominant cause of dementia.
Common symptoms include short-term memory loss, and confusion with time and place …
Common symptoms include short-term memory loss, and confusion with time and place …
Biocomputational screening of natural compounds against acetylcholinesterase
Alzheimer's disease (AD) is the most common form of dementia and is characterized by
irreversible and progressive neurodegeneration. Cholinergic dysfunction has been reported …
irreversible and progressive neurodegeneration. Cholinergic dysfunction has been reported …
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
CS Jiang, YX Ge, ZQ Cheng, JL Song, YY Wang… - Journal of Computer …, 2019 - Springer
Although the mechanism of Alzheimer's disease (AD) is still not fully understood, the
development of multifunctional AChE inhibitors remains a research focus for AD treatment …
development of multifunctional AChE inhibitors remains a research focus for AD treatment …
[HTML][HTML] Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in the context of Alzheimer's disease
Acetyl-cholinesterase enzyme (AChE) is a known target for identifying potential inhibitors
against Alzheimer diseases (AD). Therefore, it is of interest to screen AChE with the CNS …
against Alzheimer diseases (AD). Therefore, it is of interest to screen AChE with the CNS …
Identifying possible AChE inhibitors from drug-like molecules via machine learning and experimental studies
Acetylcholinesterase (AChE) is one of the most important drug targets for Alzheimer's
disease (AD) treatment. In this work, a machine learning model was trained to rapidly and …
disease (AD) treatment. In this work, a machine learning model was trained to rapidly and …
Searching for AChE inhibitors from natural compounds by using machine learning and atomistic simulations
Acetylcholinesterase (AChE) is one of the most important drug targets for Alzheimer's
disease treatment. In this work, a combined approach involving machine-learning (ML) …
disease treatment. In this work, a combined approach involving machine-learning (ML) …
Designing second generation anti-Alzheimer compounds as inhibitors of human acetylcholinesterase: Computational screening of synthetic molecules and dietary …
H Amat-ur-Rasool, M Ahmed - PLoS One, 2015 - journals.plos.org
Alzheimer's disease (AD), a big cause of memory loss, is a progressive neurodegenerative
disorder. The disease leads to irreversible loss of neurons that result in reduced level of …
disorder. The disease leads to irreversible loss of neurons that result in reduced level of …
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