Angiogenesis is a fundamental process in bone formation, remodeling, and regeneration.
Moreover, for the regeneration of bone in tissue engineering applications, it is essential to …

Adequate vascularization remains one of the major challenges in bone tissue engineering.
Since the microvascular endothelium is of benefit to osteogenesis and vascularization when …

Background and Aims Bone is a highly vascularized tissue reliant on the close spatial and
temporal connection between blood vessels and bone cells to maintain skeletal integrity …

Creating a functional vascularized bone tissue remains one of the main goals of bone tissue
engineering. Recently, a growing interest in the crosstalk between endothelial cells (EC) …

Association of the bone‐forming osteoblasts (OBs) and vascular endothelial cells (ECs) into
a biomaterial composite provides a live bone graft substitute that can repair the bone defect …

Background A dynamic vasculature is a prerequisite for bone formation where the
interaction of bone cells and endothelial cells is essential for both the development and the …

To optimize culture conditions for in vitro prevascularization of tissue-engineered bone
constructs, the development of organotypic blood vessels under osteogenic stimulatory …

Vascularization is important for bone development, fracture healing and engineering of
artificial bone tissue. In the context of bone tissue engineering, it was shown that …

Tissue engineering strategies often fail to regenerate bones because of inadequate
vascularization, especially in the reconstruction of large segmental bone defects. Large …

In the context of bone development and regeneration, the intimate association of the
vascular endothelium with osteogenic cells suggests that endothelial cells (ECs) may …