A comprehensive cellular anatomy of normal human kidney is crucial to address the cellular
origins of renal disease and renal cancer. Some kidney diseases may be cell type-specific …

Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …

The kidney is among the most complex organs in terms of the variety of cell types. The
cellular complexity of human kidneys is not fully unraveled and this challenge is further …

Background Renal cell carcinoma (RCC) is the most common type of kidney cancer.
Studying the pathogenesis of RCC is particularly important, because it could provide a direct …

Background Proximal tubule cells dominate the kidney parenchyma numerically, although
less abundant cell types of the distal nephron have disproportionate roles in water and …

Bulk-tissue RNA-Seq is increasingly being used in the study of physiological and
pathophysiological processes in the kidney; however, the presence of multiple cell types in …

Background A challenge for single-cell genomic studies in kidney and other solid tissues is
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …

Background Recent single-cell RNA sequencing (scRNA-seq) analyses have offered much
insight into cell-specific gene expression profiles in normal kidneys. However, in diseased …

Recent techniques for single-cell RNA sequencing (scRNA-seq) at high throughput are
leading to profound new discoveries in biology. The ability to generate vast amounts of …

Background Proximal tubular cells (PTCs) are the most abundant cell type in the kidney.
PTCs are central to normal kidney function and to regeneration versus organ fibrosis …