BackgroundA putative interaction between cannabis and variation at rs4680 within the
catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

BackgroundGenetic variations might modify associations between schizophrenia and
cannabis or tobacco use. AimsTo examine whether variants within the cannabinoid receptor …

Cannabis is one of the most widely used illicit drugs among adolescents, and most users
first experiment with it in adolescence. Adolescence is a critical phase for brain …

BACKGROUND: Recent evidence documents that cannabis use by young people is a
modest statistical risk factor for psychotic symptoms in adulthood, such as hallucinations and …

We have used a translational Convergent Functional Genomics (CFG) approach to discover
genes involved in alcoholism, by gene-level integration of genome-wide association study …

Despite the large toll of opioid use disorder (OUD), genome-wide association studies
(GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale …

BACKGROUND: Cannabis use is associated with an increased risk of psychosis. One study
has suggested that genetic variation in the AKT1 gene might influence this effect …

Comment 944 www. thelancet. com/psychiatry Vol 8 November 2021 with intellectual
disabilities from its mental health legislation, which resulted in increased numbers of people …

Smoking cannabis daily doubles an individual's risk of developing a psychotic disorder, yet
indicators of specific vulnerability have proved largely elusive. Genetic variation is one …