Over the past decade, peptides have emerged as a new family of potential carriers in gene
therapy. Peptides are easy to synthesize and quite stable. Additionally, sequences shared …

We recently reported on a new class of branched amphiphilic peptides that associate with
double stranded DNA and promote in vitro transfection of eukaryotic cells. In the present …

Branched amphipathic peptide capsules (BAPCs) are biologically derived, bilayer delimited,
nanovesicles capable of being coated by or encapsulating a wide variety of solutes. The …

Cationic oligopeptides fabricated from natural amino acids have been widely explored as
nonviral vectors for gene delivery, due to their biodegradability, greater biocompatibility …

This chapter will discuss cationic polymers containing ɛ-amine groups and immine or amide
linkages that are being used as nanocarriers for nonviral gene delivery. We will focus …

Cell penetrating peptides (CPPs), and protein transduction domains (PTDs) of viruses and
other natural proteins serve as a template for the development of efficient peptide based …

Arginine (Arg)-rich cell-penetrating peptides (CPPs) are promising tools for plasmid DNA
(pDNA) delivery. α-Aminoisobutyric acid (Aib) is known to stabilize peptide helical …

The renaissance gene therapy experiences these days requires specialist biomaterials and
a systemic understanding of major factors influencing their ability to deliver genetic material …

The safe and efficient delivery of nucleic acids including DNA, mRNA, siRNA, and miRNA
into targeted cells is critical for gene therapy. Currently, viral gene vectors are very popular …

To overcome the low efficiency and cytotoxicity associated with most non-viral DNA delivery
systems we developed a purely peptidic self-assembling system that is able to entrap single …