The thyroid TRK-T3 oncogene results from the fusion of the tyrosine kinase (TK) domain of
NTRK1 (one of the receptors for the Nerve Growth Factor) on chromosome 1 to sequences …

Oncogenic rearrangements of the NTRK1 gene (also designated TRKA), encoding one of
the receptors for the nerve growth factor, are frequently detected in thyroid carcinomas. Such …

The TRK-T3 oncoprotein, isolated from a human papillary thyroid tumor, arises from the
fusion between the N-terminal domain of the TFG gene and the tyrosine kinase domain of …

The NTRK1 gene in the q arm of chromosome I encodes one of the receptors for the nerve
growth factor and is frequently activated as an oncogene in papillary thyroid carcinomas …

The TRK-T1 oncogene, isolated from a human thyroid carcinoma, represents a rearranged
form of the high affinity nerve growth factor (NGF) receptor encoded by the NTRK1 gene; it is …

Genetic analysis of human papillary thyroid carcinomas (PTC) has revealed unique
chromosomal translocations that form oncogenic fusion proteins and promote thyroid …

TRK oncogenes are created by chromosomal rearrangements linking the tyrosine-kinase
domain of the NTRK1 gene (encoding one of the receptors for the nerve growth factor) to …

Papillary thyroid carcinoma arises from the thyroid epithelium, a tissue simple and
homogenous in its organization, behaviour and differentiation, whose growth is regulated by …

We have recently reported the frequent activation of the TRK oncogene in human papillary
thyroid carcinoma. In this paper we describe the isolation and characterization of one of the …

The thyroid TRK-T3 oncogene, produced by a chromosomal translocation, is a chimeric,
constitutively activated version of the NTRK1/NGF receptor and it is able to transform …