Irritability cuts across many pediatric disorders and is a common presenting complaint in
child psychiatry; however, its neural mechanisms remain unclear. One core …

Objective Aberrant responses to frustration are central mechanisms of pediatric irritability,
which is a common reason for psychiatric consultation and a risk factor for affective disorders …

Objective: Childhood irritability is a common, impairing problem with changing age-related
manifestations that predict long-term adverse outcomes. However, more investigation of …

Irritability is impairing and prevalent across pediatric psychiatric disorders and typical
development, yet its neural mechanisms are largely unknown. This study evaluated the …

Objective Childhood irritability, operationalized as disproportionate and frequent temper
tantrums and low frustration tolerance relative to peers, is a transdiagnostic symptom across …

Pediatric irritability is the most robust indicator of transdiagnostic psychopathology risk. It is
associated with altered neural reward processing, including neural networks related to …

Irritability, conceptualized as a lowered frustration response threshold to blocked goal
attainment (ie, frustrative nonreward), is a common, detrimental symptom in adolescence …

Objective Irritability is common in children and adolescents and is the cardinal symptom of
disruptive mood dysregulation disorder, a new DSM-5 disorder, yet its neural correlates …

Background Irritability, a relatively lowered threshold for anger, is prevalent in typically and
atypically developing youths. Inhibitory control, the ability to suppress behaviors counter to …

Burgeoning interest in early childhood irritability has recently turned toward neuroimaging
techniques to better understand normal versus abnormal irritability using dimensional …