Tissue‐engineered bone provides a promising method for the rehabilitation of acquired
bone defects and congenital deformities. However, generating a vascular supply to the …

Over-dependence on existing synthetic scaffolds and insufficient vascularization limit the
development of tissue engineered bone (TEB). The purpose of this study is to fabricate …

Tissue engineering strategies often fail to regenerate bones because of inadequate
vascularization, especially in the reconstruction of large segmental bone defects. Large …

Natural bone growth greatly depends on the precedent vascular network that supplies
oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue …

Objectives The bone tissue engineering primarily focuses on three‐dimensional co‐culture
systems, which physical and biological properties resemble the cell matrix of actual tissues …

In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered
bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen …

Currently, most in vitro engineered bone tissues do not contain viable blood vessel systems,
so the vascularization depends on post-implantation angiogenesis from the host, which is …

In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

Rapid vascularisation of tissue-engineered osteogenic grafts is a major obstacle in the
development of regenerative medicine approaches for bone repair. Vascular endothelial …

To introduce a functional vascular network into tissue‐engineered bone equivalents, human
endothelial colony forming cells (ECFCs) and multipotent mesenchymal stromal cells …