Sub-dominant principal components inform new vaccine targets for HIV Gag
Motivation Patterns of mutational correlations, learnt from patient-derived sequences of
human immunodeficiency virus (HIV) proteins, are informative of biochemically linked …
human immunodeficiency virus (HIV) proteins, are informative of biochemically linked …
Evolutionary dynamics of HIV at multiple spatial and temporal scales
Infectious diseases remain a formidable challenge to human health, and understanding
pathogen evolution is crucial to designing effective therapeutics and control strategies. Here …
pathogen evolution is crucial to designing effective therapeutics and control strategies. Here …
Leveraging hierarchical population structure in discrete association studies
Population structure can confound the identification of correlations in biological data. Such
confounding has been recognized in multiple biological disciplines, resulting in a disparate …
confounding has been recognized in multiple biological disciplines, resulting in a disparate …
Host–parasite network structure is associated with community-level immunogenetic diversity
Genes of the major histocompatibility complex (MHC) encode proteins that recognize foreign
antigens and are thus crucial for immune response. In a population of a single host species …
antigens and are thus crucial for immune response. In a population of a single host species …
Extensive host immune adaptation in a concentrated North American HIV epidemic
Objective: HIV incidence in the Canadian province of Saskatchewan, where Indigenous
persons make up 80% of those infected, are among the highest on the continent. Reports of …
persons make up 80% of those infected, are among the highest on the continent. Reports of …
Adaptation to human populations is revealed by within-host polymorphisms in HIV-1 and hepatitis C virus
AFY Poon, SL Kosakovsky Pond, P Bennett… - PLoS …, 2007 - journals.plos.org
CD8+ cytotoxic T-lymphocytes (CTLs) perform a critical role in the immune control of viral
infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and …
infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and …
The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery
BE Aouizerat, CL Pearce, C Miaskowski - Current HIV/AIDS Reports, 2011 - Springer
Though pursuit of host genetic factors that influence the pathogenesis of HIV began over two
decades ago, progress has been slow. Initial genome-level searches for variations …
decades ago, progress has been slow. Initial genome-level searches for variations …
Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression
DC Mónaco, DA Dilernia, A Fiore-Gartland… - Journal of Experimental …, 2016 - rupress.org
HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we
evaluate the impact on viral control and disease progression of transmitted polymorphisms …
evaluate the impact on viral control and disease progression of transmitted polymorphisms …
Is HIV short-sighted? Insights from a multistrain nested model
An important component of pathogen evolution at the population level is evolution within
hosts. Unless evolution within hosts is very slow compared to the duration of infection, the …
hosts. Unless evolution within hosts is very slow compared to the duration of infection, the …
GuavaH: a compendium of host genomic data in HIV biology and disease
Background There is an ever-increasing volume of data on host genes that are modulated
during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV …
during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV …