Gene expression variability within and between human populations and implications toward disease susceptibility
Variations in gene expression level might lead to phenotypic diversity across individuals or
populations. Although many human genes are found to have differential mRNA levels …
populations. Although many human genes are found to have differential mRNA levels …
Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models
The mechanisms triggering the human immunodeficiency virus type I (HIV-1) to switch the
coreceptor usage from CCR5 to CXCR4 during the course of infection are not entirely …
coreceptor usage from CCR5 to CXCR4 during the course of infection are not entirely …
Pathogen selection drives nonoverlapping associations between HLA loci
Pathogen-mediated selection is commonly invoked as an explanation for the exceptional
polymorphism of the HLA gene cluster, but its role in generating and maintaining linkage …
polymorphism of the HLA gene cluster, but its role in generating and maintaining linkage …
Phylogenetic patterns recover known HIV epidemiological relationships and reveal common transmission of multiple variants
T Leitner, E Romero-Severson - Nature microbiology, 2018 - nature.com
The growth of human immunodeficiency virus (HIV) sequence databases resulting from drug
resistance testing has motivated efforts using phylogenetic methods to assess how HIV …
resistance testing has motivated efforts using phylogenetic methods to assess how HIV …
Scaling laws describe memories of host–pathogen riposte in the HIV population
The enormous genetic diversity and mutability of HIV has prevented effective control of this
virus by natural immune responses or vaccination. Evolution of the circulating HIV …
virus by natural immune responses or vaccination. Evolution of the circulating HIV …
HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification
The recent HIV-1 vaccine failures highlight the need to better understand virus-host
interactions. One key question is why CD8+ T cell responses to two HIV-Gag regions are …
interactions. One key question is why CD8+ T cell responses to two HIV-Gag regions are …
Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model
O DeLeon, H Hodis, Y O'Malley, J Johnson… - PLoS …, 2017 - journals.plos.org
The envelope glycoproteins (Envs) of HIV-1 continuously evolve in the host by random
mutations and recombination events. The resulting diversity of Env variants circulating in the …
mutations and recombination events. The resulting diversity of Env variants circulating in the …
Inspecting the interaction between HIV and the immune system through genetic turnover
Chronic infections of the human immunodeficiency virus (HIV) create a very complex co-
evolutionary process, where the virus tries to escape the continuously adapting host immune …
evolutionary process, where the virus tries to escape the continuously adapting host immune …
Weaker HLA footprints on HIV in the unique and highly genetically admixed host population of Mexico
M Soto-Nava, S Avila-Rios… - Journal of …, 2018 - Am Soc Microbiol
ABSTRACT HIV circumvents HLA class I-restricted CD8+ T-cell responses through selection
of escape mutations that leave characteristic mutational “footprints,” also known as HLA …
of escape mutations that leave characteristic mutational “footprints,” also known as HLA …
HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation
Objective: HIV-1 frequently adapts in response to immune pressure from cytotoxic T-
lymphocytes (CTL). Many HIV-2 infected individuals have robust capsid-specific CTL …
lymphocytes (CTL). Many HIV-2 infected individuals have robust capsid-specific CTL …