Highlights•Systems vaccinology will guide the design of new vaccination strategies for
HIV.•Pre-vaccination gene expression signatures can predict response to vaccines.•We …

The high diversity of HLA binding preferences has been driven by the sequence diversity of
short segments of relevant pathogenic proteins presented by HLA molecules to the immune …

Genome-wide association studies (GWAS) have been successful in identifying and
confirming novel genetic variants that are associated with diverse HIV phenotypes …

Twenty-five years after the discovery of HIV as the cause of AIDS there is still no effective
vaccine and no cure for this disease. HIV susceptibility shows a substantial degree of …

Increasingly efficient methods for inferring the ancestral origin of genome regions are
needed to gain new insights into genetic function and history as biobanks grow in scale …

The rapid evolution of HIV is constrained by interactions between mutations which affect
viral fitness. In this work, we explore the role of epistasis in determining the mutational …

Host genetic variation is presently estimated to account for about one-fourth of the observed
differences in control of HIV across infected individuals. Genome-wide association studies …

The rapid evolution of HIV is constrained by interactions between mutations which affect
viral fitness. In this work, we explore the role of epistasis in determining the fitness …

Despite the success of highly active antiretroviral therapy (HAART) in the management of
human immunodeficiency virus (HIV)-1 infection, virological failure due to drug resistance …

Background Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-
level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these …