To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of
systems pharmacology will be integrated using structured ontological approaches, analytics …

Systems approaches have long been used in pharmacology to understand drug action at
the organ and organismal levels. The application of computational and experimental …

Systems pharmacology aims to holistically understand mechanisms of drug actions to
support drug discovery and clinical practice. Systems pharmacology modeling (SPM) is data …

Introduction: The conventional one-drug-one-target-one-disease drug discovery process
has been less successful in tracking multi-genic, multi-faceted complex diseases. Systems …

Abstract Systems pharmacology involves the application of systems biology approaches,
combining large‐scale experimental studies with computational analyses, to the study of …

There is notable interindividual heterogeneity in drug response, affecting both drug efficacy
and toxicity, resulting in patient harm and the inefficient utilization of limited healthcare …

Genome medicine uses genomic information in the diagnosis of disease and in prescribing
treatment. This transdisciplinary field brings together knowledge on the relationships …

An important challenge facing researchers in drug development is how to translate multi-
omic measurements into biological insights that will help advance drugs through the clinic …

A crucial question that must be addressed in the drug development process is whether the
proposed therapeutic target will yield the desired effect in the clinical population …

Modeling and simulation (M&S) techniques provide a platform for knowledge integration and
hypothesis testing to gain insights into biological systems that would not be possible a priori …